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Treatment discontinuation may be considered in persons who have demonstrated loss of HBsAg.

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For these patients, discontinuation of treatment is accompanied by a reversion to a wild type of HBV and a flare of the disease.

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On the basis of this result, several treatment guidelines currently recommend that the data from our study be considered in selecting NRTIs for patients with high HIV-1 RNA levels who have not received antiretroviral treatment.

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The second major advance came with the availability of highly effective and well-tolerated antiviral agents against HBV, such as lamivudine, adefovir dipivoxil, and more recently, entecavir and tenafovir, which improved the outcomes of patients with decompensated cirrhosis awaiting transplantation as well as transplant recipients who had recurrent HBV disease.

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